Cyclin L1 Colorimetric Cell-Based ELISA Kit

• Description:

  The Cyclin L1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Cyclin L1 protein expression profile in cells. The kit can be used for measuring the relative amounts of Cyclin L1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Cyclin L1.

• Synonyms:

  Cyclin-L1; Cyclin-L; CCNL1

• Gene Name:

  CCNL1

• UniProt:

  Q9UK58

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Widely expressed. Overexpression in primary tumors of head and neck squamous cell carcinomas (HNSCC) .

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018) . Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906) . May play a role in the regulation of RNA polymerase II (pol II) . May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036) .

• Molecular Weight:

  59634 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Cyclin-L1

• Subcellular Location:

  Nucleus speckle. Nucleus, nucleoplasm. Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.