Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody

• Background:

  Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996) . The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999) . Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004) .

• Description:

  Boster Bio Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody (Catalog # P06871) . Tested in WB, IHC, ICC applications. This antibody reacts with Hamster, Mouse, Rat.

• Phospho Site:

  Phosphorylated, Ser503

• Synonyms:

  C230009H10Rik antibody, FLJ41162 antibody, FLJ42249 antibody, FLJ43491 antibody, Kcnc1 antibody, KCNC1 antibody, KCNC1_HUMAN antibody, Kcr2 1 antibody, KShIIIB antibody, Kv3.1 antibody, Kv4 antibody, MGC129855 antibody, NGK2 antibody, Potassium voltage-gated channel subfamily C member 1 antibody, Shaw antibody, Voltage gated potassium channel antibody, Voltage gated potassium channel subunit Kv3.1 antibody, Voltage-gated potassium channel subunit Kv3.1 antibody, Voltage-gated potassium channel subunit Kv4 antibody

• Gene Name:

  KCNC1

• UniProt:

  P25122

• Host:

  Rabbit

• Reactivity:

  Hamster, Mouse, Rat

• Immunogen:

  The antigen is a phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of the rat voltage-gated potassium channel Kv3.1, conjugated to keyhole limpet hemocyanin (KLH) . Immunogen species is Rat.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in globus pallidal neurons of the basal ganglia (at protein level) (PubMed:10482766) . Brain (PubMed:1378392) .

• Applications:

  WB, IHC, ICC

• Field of Research:

  Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

• Purification:

  Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Function:

  Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10482766, PubMed:14679187) . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766, PubMed:14679187) . Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766) .

• Molecular Weight:

  65857 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

• Fragment:

  IgG

• Applications Notes:

  Specific for endogenous levels of the ~100 kDa Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.

• Other Gene Names:

  Potassium voltage-gated channel subfamily C member 1

• Subcellular Location:

  Cell membrane ; Multi- pass membrane protein.

• Protein Name:

  Potassium voltage-gated channel subfamily C member 1