Anti-Phospho-MLK3 (Ser674) MAP3K11 Antibody

• Description:

  Boster Bio Anti-Phospho-MLK3 (Ser674) MAP3K11 Antibody (Catalog # P04412) . Tested in WB, ELISA applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Mitogen-activated protein kinase kinase kinase 11;2.7.11.25; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase; MAP3K11 ; MLK3 , PTK1, SPRK

• Gene Name:

  MAP3K11

• UniProt:

  Q16584

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from human MLK3 around the phosphorylation site of S674.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain. .

• Applications:

  WB, ELISA

• Field of Research:

  Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Tyrosine Kinases

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. .

• Molecular Weight:

  92688 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Mitogen-activated protein kinase kinase kinase 11

• Subcellular Location:

  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Location is cell cycle dependent.