Anti-Phospho-Synapsin I (Ser62,67) Syn1 Antibody

• Background:

  Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996) . This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. The role of synapsin in synaptic plasticity and in synaptogenesis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002) . Ser-549 along with Ser-62 and Ser-67 are the sites of Synapsin I that are phosphorylated by MAP kinase (Czernik et al., 1987; Jovanovic et al., 1996) .

• Description:

  Boster Bio Anti-Phospho-Synapsin I (Ser62, 67) Syn1 Antibody (Catalog # P03794-2) . Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Phospho Site:

  Phosphorylated, Ser62,67

• Synonyms:

  Brain protein 4.1 antibody, SYN 1 antibody, SYN 1a antibody, SYN 1b antibody, SYN I antibody, SYN1 antibody, SYN1_HUMAN antibody, SYN1a antibody, SYN1b antibody, Synapsin 1 antibody, Synapsin I antibody, Synapsin-1 antibody, Synapsin1 antibody, SynapsinI antibody, SYNI antibody

• Gene Name:

  SYN1

• UniProt:

  P17599

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser62/67 of rat synapsin, conjugated to keyhole limpet hemocyanin (KLH) . Immunogen species is Rat.

• Clonality:

  Polyclonal

• Applications:

  WB

• Field of Research:

  Cancer, Cancer Susceptibility, Epigenetics and Nuclear Signaling, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Transcription

• Purification:

  Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Dilution:

  WB: 1:1000

• Form:

  Liquid

• Function:

  Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level.

• Molecular Weight:

  74097 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.

• Fragment:

  IgG

• Applications Notes:

  Specific for endogenous levels of the ~78 kDa synapsin I doublet phosphorylated at Ser62,67. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.

• Other Gene Names:

  Synapsin-1

• Subcellular Location:

  Cell junction, synapse. Golgi apparatus.

• Prediction Reactivity:

  Bovine

• Protein Name:

  Synapsin-1