Anti-CD11a / Integrin alphaL / LFA-1 alpha Chain Monoclonal Antibody

• Background:

  Recognizes a protein of 180kDa, identified as CD11a (Leucocyte Workshop II; Code N202) . CD11a complex with the 2 subunit of the integrin family, CD18, to form the cell surface heterodimer, LFA-1 or CD11a /C18 (aLbL) . LFA-1 is expressed on all leukocytes including lymphocytes, monocytes, and granulocytes. It is involved in leukocyte adhesion to its ligands including intercellular adhesion molecule-1 (ICAM-1 or CD54), ICAM-2 (CD102), ICAM-3 (CD50) and Telencephalin (TLN) and play a role in most immune/inflammatory responses.

• Description:

  Boster Bio Anti-CD11a / Integrin alphaL / LFA-1 alpha Chain Monoclonal Antibody (Catalog # M04466) . Tested in Flow Cytometry, IF, Functional Assay applications. This antibody reacts with Human.

• Synonyms:

  Integrin alpha-L; CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11a; ITGAL; CD11A

• Gene Name:

  ITGAL

• UniProt:

  P20701

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Stimulated human leukocytes

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: CRIS-3

• Tissue Specificity:

  Leukocytes.

• Applications:

  Flow Cytometry, IF, Functional Assay

• Field of Research:

  Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

• Purification:

  200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

• Concentration:

  Purified antibody with BSA and azide at 200ug/ml

• Form:

  Liquid

• Function:

  Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

• Molecular Weight:

  128770 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Fragment:

  IgG2b, kappa

• Other Gene Names:

  Integrin alpha-L

• Subcellular Location:

  Cell Surface