Anti-Laminin beta 1 LAMB1 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-Laminin beta 1 LAMB1 Rabbit Monoclonal Antibody catalog # M03894. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Laminin subunit beta-1; Laminin B1 chain; Laminin-1 subunit beta; Laminin-10 subunit beta; Laminin-12 subunit beta; Laminin-2 subunit beta; Laminin-6 subunit beta; Laminin-8 subunit beta; LAMB1

• Gene Name:

  Laminin subunit beta-1

• UniProt:

  P07942

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human Laminin beta 1

• Clonality:

  Monoclonal

• Clone:

  Clone: AODF-12

• Tissue Specificity:

  Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies.

• Applications:

  WB, Flow Cytometry

• Field of Research:

  Angiogenesis, Cardiovascular, Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:500-1:2000
  FC 1:50

• Other Gene Names:

  LAMB1

• Subcellular Location:

  Secreted, extracellular space, extracellular matrix, basement membrane. Major component.

• Protein Name:

  T-cell surface glycoprotein CD3 zeta chain