Anti-PI 3 Kinase Class 3 PIK3C3 Rabbit Monoclonal Antibody

Anti-PI 3 Kinase Class 3 PIK3C3 Rabbit Monoclonal Antibody

• Description: Boster Bio Anti-PI 3 Kinase Class 3 PIK3C3 Rabbit Monoclonal Antibody catalog # M02356. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
• Synonyms: Phosphatidylinositol 3-kinase catalytic subunit type 3;PI3-kinase type 3;PI3K type 3;PtdIns-3-kinase type 3;2.7.1.137;Phosphatidylinositol 3-kinase p100 subunit;Phosphoinositide-3-kinase class 3;hVps34;PIK3C3;VPS34;
• CAS Number: 9007-83-4
• Gene Name: Phosphatidylinositol 3-kinase catalytic subunit type 3
• UniProt: Q8NEB9
• Host: Rabbit
• Reactivity: Human,Mouse,Rat
• Immunogen: A synthesized peptide derived from human PI 3 Kinase Class 3
• Clonality: Monoclonal
• Clone: Clone: CDO-16
• Tissue Specificity: Ubiquitously expressed, with a highest expression in skeletal muscle. .
• Applications: WB,IHC
• Purification: Affinity-chromatography
• Concentration: Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
• Form: Liquid
• Reconstitution: Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL
• Function: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123, PubMed:20208530). Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes (By similarity). .
• Components: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
• Storage Conditions: Store at -20℃ for one year. For short term storage and frequent use, store at 4℃ for up to one month. Avoid repeated freeze-thaw cycles.
• Calculated Molecular Weight: 101549 MW
• Observed Molecular Weight: 100 kDa
• Fragment: Rabbit IgG
• Applications Notes: WB 1:500-1:2000
  IHC 1:50-1:200
• Subcellular Location: Midbody . Late endosome . Cytoplasmic vesicle, autophagosome . As component of the PI3K complex I localized to pre-autophagosome structures. As component of the PI3K complex II localized predominantly to endosomes (Probable). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). .
• Protein Name: Lysosome-associated membrane glycoprotein 2 (Lamp2)