Anti-IAP2 BIRC3 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-IAP2 BIRC3 Rabbit Monoclonal Antibody catalog # M01562. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human.

• Synonyms:

  Baculoviral IAP repeat-containing protein 3;6.3.2.-; Apoptosis inhibitor 2; API2; C-IAP2; IAP homolog C; Inhibitor of apoptosis protein 1; IAP-1; hIAP-1; hIAP1; RING finger protein 49; TNFR2-TRAF-signaling complex protein 1; BIRC3; API2, IAP1, MIHC, RNF49

• Gene Name:

  Baculoviral IAP repeat-containing protein 3

• UniProt:

  Q13489

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthesized peptide derived from human IAP2

• Clonality:

  Monoclonal

• Clone:

  Clone: BOB-2

• Tissue Specificity:

  Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.

• Applications:

  WB, IHC, ICC, IF, IP

• Field of Research:

  Angiogenesis, Cardiovascular, Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Myeloid, Signal Transduction, Stem Cells

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin- protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite ions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin- protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs) . Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase- independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:1000-1:2000
  IHC 1:50-1:100
  ICC/IF 1:50-1:100
  IP 1:50

• Other Gene Names:

  BIRC3

• Subcellular Location:

  Cytoplasm . Nucleus .

• Protein Name:

  Glycogen synthase kinase-3 beta (gsk3b)