Anti-Hexokinase 1 HK1 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-Hexokinase 1 HK1 Rabbit Monoclonal Antibody catalog # M01504. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Hexokinase-1;2.7.1.1; Brain form hexokinase; Hexokinase type I; HK I; HK1

• Gene Name:

  Hexokinase-1

• UniProt:

  P19367

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human Hexokinase 1

• Clonality:

  Monoclonal

• Clone:

  Clone: EOF-8

• Tissue Specificity:

  Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific.

• Applications:

  WB, IHC, ICC, IF, Flow Cytometry

• Field of Research:

  T Lymphocytic Lineage

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G (i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity) . Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3- phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200
  FC 1:200

• Other Gene Names:

  HK1

• Subcellular Location:

  Mitochondrion outer membrane. Its hydrophobic N-terminal sequence may be involved in membrane binding.

• Protein Name:

  Glycogen synthase kinase-3 beta (gsk3b)