Anti-SERCA2 ATP2A2 Rabbit Monoclonal Antibody

• Description:

  Boster Bio Anti-SERCA2 ATP2A2 Rabbit Monoclonal Antibody catalog # M01176. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca (2+) -ATPase 2;3.6.3.8; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca (2+) ATPase; ATP2A2; ATP2B

• Gene Name:

  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

• UniProt:

  P16615

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthesized peptide derived from human SERCA2

• Clonality:

  Monoclonal

• Clone:

  Clone: AOGE-1

• Tissue Specificity:

  Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. .

• Applications:

  WB, IHC, ICC, IF, Flow Cytometry

• Field of Research:

  ATPases, Calcium Channels, Calcium Signaling, Cancer, Cardiovascular, Cofactors, Vitamins/Minerals, Contractility, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction, Signaling Pathway, Vitamins/Minerals

• Purification:

  Affinity-chromatography

• Concentration:

  Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Reconstitution:

  Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

• Function:

  This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. .

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Applications Notes:

  WB 1:500-1:2000
  IHC 1:50-1:200
  ICC/IF 1:50-1:200
  FC 1:50

• Other Gene Names:

  ATP2A2

• Subcellular Location:

  Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

• Protein Name:

  Glycogen synthase kinase-3 beta (gsk3b)