Anti-Tenascin C (Stromal Marker For Epithelial Malignancy) Monoclonal Antibody

• Background:

  In Western blotting, it reacts with two bands of ~MW of 210kDa and 300kDa, identified as two isoforms of Tenascin C. Specificity of This monoclonal antibody is validated by sequential immunoprecipitation with a PAb against Tenascin C. Tenascin C is a multifunctional, disulfide-linkedhexameric extracellular matrix glycoprotein expressed in association with mesenchymal epithelial interactions during development and in the neo-vasculature and stroma of undifferentiated tumors. In adults, it is restricted to certain epithelial-stromal interfaces and increases markedly in hyper-proliferative diseases and in stroma of many neoplasms, including gliomas, breast, squamous and lung carcinomas.

• Description:

  Boster Bio Anti-Tenascin C (Stromal Marker For Epithelial Malignancy) Monoclonal Antibody (Catalog # M00936) . Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human.

• Synonyms:

  Tenascin; TN; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C; TNC; HXB

• Gene Name:

  TNC

• UniProt:

  P24821

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Human breast carcinoma

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: SPM319

• Applications:

  Flow Cytometry, IF, IHC

• Field of Research:

  Cell Adhesion Proteins, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Mesenchymal Stem Cells, Neural Signal Transduction, Neural Stem Cells, Neurology Process, Neuroscience, Secreted Molecules, Signal Transduction, Stem Cells

• Purification:

  200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.

• Concentration:

  Purified antibody with BSA and azide at 200ug/ml

• Form:

  Liquid

• Function:

  Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

• Molecular Weight:

  240853 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Fragment:

  IgG1, kappa

• Other Gene Names:

  Tenascin

• Subcellular Location:

  Connective tissue matrix