Anti-Integrin alpha 4 (ITGA4) Rabbit Monoclonal Antibody, Clone#RM268

• Description:

  Boster Bio Anti-Integrin alpha 4 (ITGA4) Rabbit Monoclonal Antibody, Clone#RM268 (Catalog # M00468-1) . Tested in IHC, WB applications. This antibody reacts with Human.

• Synonyms:

  Integrin alpha-4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d; ITGA4; CD49D

• Gene Name:

  ITGA4

• UniProt:

  P13612

• Host:

  Rabbit

• Reactivity:

  Human

• Cross Reactivity:

  This antibody reacts to the cytoplasmic domain of human Integrin alpha 4 (ITGA4) .

• Immunogen:

  A peptide corresponding to the C-terminus of human Integrin alpha 4 (ITGA4) .

• Clonality:

  Monoclonal

• Clone:

  Clone: RM268

• Applications:

  IHC, WB

• Field of Research:

  Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Immunology, Integrins, Neural Stem Cells, Signal Transduction, Stem Cells, Surface Molecules

• Purification:

  Protein A affinity purified from an animal origin-free culture supernatant

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Function:

  Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415) . ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877) .

• Molecular Weight:

  114900 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Other Gene Names:

  Integrin alpha-4

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.