Anti-FLI1 (Ewing s Sarcoma & Endothelial Marker) Monoclonal Antibody

• Background:

  Recognizes a protein of 51kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus.Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing's Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t (11;22) (q24; q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi's Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.

• Description:

  Boster Bio Anti-FLI1 (Ewing s Sarcoma & Endothelial Marker) Monoclonal Antibody (Catalog # M00399) . Tested in Flow Cytometry, IF, WB applications. This antibody reacts with Human.

• Synonyms:

  Friend leukemia integration 1 transcription factor; Proto-oncogene Fli-1; Transcription factor ERGB; FLI1

• Gene Name:

  FLI1

• UniProt:

  Q01543

• Host:

  Mouse

• Reactivity:

  Human

• Immunogen:

  Recombinant fragment (aa 107-261) of human FLI1 protein with hexa-histidine tag

• Clonality:

  Monoclonal

• Clone:

  Clone: Clone: FLI1/1312

• Applications:

  Flow Cytometry, IF, WB

• Field of Research:

  Apoptosis, Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Death,2339, Domain Families, Epigenetics and Nuclear Signaling, Metabolism, Metabolism Processes, Nuclear, Nucleus, Pathways and Processes, Proto-Oncogenes, Transcription

• Purification:

  200ug/ml of antibody purified from rabbit anti-serum by Protein A.

• Concentration:

  Purified antibody with BSA and azide at 200ug/ml

• Form:

  Liquid

• Function:

  Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

• Molecular Weight:

  50982 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

• Fragment:

  IgG1, kappa

• Other Gene Names:

  Friend leukemia integration 1 transcription factor

• Subcellular Location:

  Nuclear