Anti-NEURL1 Antibody

• Description:

  Boster Bio Anti-NEURL1 Antibody (Catalog# A30740) . Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Rat, Mouse.

• Synonyms:

  NEURL; NEURL1; NEURL1A; RNF67; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67

• Gene Name:

  NEURL1

• UniProt:

  O76050

• Host:

  Rabbit

• Reactivity:

  Human, Rat, Mouse

• Immunogen:

  A peptide derived from human NEURL1. Immunogen sequence location: 219-268

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in brain, testis, pituitary gland, pancreas and bone marrow. Also poorly expressed in an malignant astrocytomas and several neuroectodermal tumor cell lines. Weakly expressed in medulloblastoma (MB) compared with normal cerebellar tissues.

• Applications:

  WB, IHC-P, IF (paraffin), ELISA

• Field of Research:

  Epigenetics and Nuclear Signaling, Ubiquitin & Ubiquitin Like Modifiers

• Purification:

  The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

• Sensitivity:

  >5000 cells

• Concentration:

  0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

• Form:

  Liquid

• Function:

  Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element- binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.

• Molecular Weight:

  61860 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Other Gene Names:

  E3 ubiquitin-protein ligase NEURL1

• Subcellular Location:

  Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, dendrite. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Localized in the cell bodies of the pyramidal neurons and distributed along their apical dendrites. Colocalized with PSD95 in postsynaptic sites. Colocalized with CPEB3 at apical dendrites of CA1 neurons (By similarity) . Colocalized with JAG1 at the cell surface.