Anti-ALG6 Antibody

CAT: 0519-A07747Size: 100 µLDry Ice: YesHazardous: No

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CAT#:0519-A07747Size:100 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Anti-ALG6 antibody was designed, produced, and validated as part of the Joy Cappel Young Investigator Award (JCYIA) . Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase is an enzyme that is encoded by the ALG6 gene in humans. This gene encodes ALG6/ALG8 member of glucosyltransferase family. The encoded protein catalyzes the addition of the first glucose residue to the growing lipid-linked oligosaccharide precursor of N-linked glycosylation. Mutations in this gene are associated with congenital disorders of glycosylation type. Anti-ALG6 is ideal for researchers interested in Infectious disease, especially HIV and hepatitis virus infections. Anti-ALG6 antibody is applicable to methods for diagnosis and, in particular, to methods for diagnosing infections using biomarkers targeting exosomes secreted in bodily fluids.

Description

Boster Bio Anti-ALG6 Antibody (Catalog # A07747) . Tested in ELISA, IHC, WB applications. This antibody reacts with Human.

Synonyms

ALG6, ALG-6, Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase, Asparagine-linked glycosylation protein 6 homolog, Dol-P-Glc:Man (9) GlcNAc (2) -PP-Dol alpha-1,3-glucosyltransferase, Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase, ALG6, My046

Gene Name

ALG6

UniProt

Q9Y672

Host

Rabbit

Reactivity

Human

Immunogen

This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide, corresponding to a region near the N-terminus of human ALG6 protein, conjugated to KLH.

Clonality

Polyclonal

Applications

ELISA, IHC, WB

Field of Research

Organelles, Subcellular Markers, Tags & Cell Markers

Purification

ALG6 Antibody antiserum is directed against human ALG6. A 58 kDa band is detected when assayed by immunoblot. Cross-reactivity is expected against human ALG6 protein based on a 100% homology of the amino acid sequence of the immunogen between rat, mouse, drosophila, and pongo abelii.

Concentration

80 mg/mL by Refractometry

Form

Liquid (sterile filtered)

Function

Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man (9) GlcNAc (2) -PP-Dol.

Molecular Weight

58181 MW

Shipping Conditions

Due to dry ice shipping issues, this product is temporarily not available to distributors outside of the United States.

Storage Conditions

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Fragment

IgG

Applications Notes

Anti-ALG6 antibody has been tested in ELISA, western blot, and immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 58kDa in size corresponding to ALG6 protein by Western blotting in the appropriate cell lysate or extract.

Other Gene Names

Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

Subcellular Location

Endoplasmic reticulum membrane ; Multi-pass membrane protein.

UniProtKB · Q9Y672

Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

ALG6_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9Y672
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ALG6
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.4.1.267
Processing: —
Secondary accessions: B3KMU2, Q5SXR9, Q9H3I0

Protein keywords

Disease

Congenital disorder of glycosylationDisease variant

Cellular component

Endoplasmic reticulumMembrane

PTM

Glycoprotein

Molecular function

GlycosyltransferaseTransferase

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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PAab00308	Anti-ALG6 antibody
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