Anti-HLA-DOA/Hla Doa Antibody

• Background:

  Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.
  
  Trowsdale J., EMBO J. 4:2231-2237(1985).
  Jonsson A.-K., Immunogenetics 29:411-413(1989).
  Young J.A., Immunogenetics 31:386-388(1990).

• Description:

  Boster Bio Anti-HLA-DOA/Hla Doa Antibody (Catalog # A06776) . Tested in WB applications. This antibody reacts with Human.

• Synonyms:

  HLA class II histocompatibility antigen, DO alpha chain; MHC DN-alpha; MHC DZ alpha; MHC class II antigen DOA; HLA-DOA; HLA-DNA, HLA-DZA

• Gene Name:

  HLA-DOA

• UniProt:

  P06340

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthesized peptide derived from internal of human HLA-DOA.

• Clonality:

  Polyclonal

• Applications:

  WB

• Field of Research:

  Adaptive Immunity, Immunology

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  Western blotting: 1:500~1:3000

• Form:

  Liquid

• Function:

  Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

• Molecular Weight:

  27599 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  HLA class II histocompatibility antigen, DO alpha chain

• Subcellular Location:

  Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.