Anti-HARS/Hisrs Antibody

• Background:

  Defects in HARS are a cause of Usher syndrome type 3B (USH3B). USH3B is a syndrome characterized by progressive vision and hearing loss during early childhood. Some patients have the so-called 'Charles Bonnet syndrome, ' involving decreased visual acuity and vivid visual hallucinations. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa with sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH3 is characterized by postlingual, progressive hearing loss, variable vestibular dysfunction, and onset of retinitis pigmentosa symptoms, including nyctalopia, constriction of the visual fields, and loss of central visual acuity, usually by the second decade of life. Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  Raben N., Nucleic Acids Res. 20:1075-1081(1992).
  Tsui F.W.L., Nucleic Acids Res. 15:3349-3367(1987).
  Tsui H.W., Gene 131:201-208(1993).

• Description:

  Boster Bio Anti-HARS/Hisrs Antibody (Catalog # A05242) . Tested in WB, IF applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Histidine--tRNA ligase, cytoplasmic;6.1.1.21; Histidyl-tRNA synthetase; HisRS; HARS; HRS

• Gene Name:

  HARS

• UniProt:

  P12081

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from C-terminal of human HARS.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Brain, heart, liver and kidney.

• Applications:

  WB, IF

• Field of Research:

  Autoimmune, DNA/RNA, Epigenetics and Nuclear Signaling, Immune System Diseases, Immunology, Translation

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Cytoplasmic histidine--tRNA ligase (Probable) . Plays a role in axon guidance. .

• Molecular Weight:

  57411 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Histidine--tRNA ligase, cytoplasmic

• Subcellular Location:

  Cytoplasm.