Anti-TRIM29 Antibody (Center)

• Background:

  The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.

• Description:

  Boster Bio Anti-TRIM29 Antibody (Center) (Catalog # A04472) . Tested in WB application (s) . This antibody reacts with Human.

• Synonyms:

  Tripartite motif-containing protein 29, Ataxia telangiectasia group D-associated protein, TRIM29, ATDC

• Gene Name:

  TRIM29

• UniProt:

  Q14134

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TRIM29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the Central region of human TRIM29.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in placenta, prostate and thymus.

• Applications:

  WB

• Field of Research:

  Cell Biology

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Dilution:

  WB: 1:1000

• Function:

  Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.

• Molecular Weight:

  65835 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Subcellular Location:

  Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments

• Prediction Reactivity:

  Mouse