Anti-SMYD2/Kmt3C Antibody

• Description:

  Boster Bio Anti-SMYD2/Kmt3C Antibody catalog # A04281. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  N-lysine methyltransferase SMYD2;2.1.1.-; HSKM-B; Histone methyltransferase SMYD2;2.1.1.43; Lysine N-methyltransferase 3C; SET and MYND domain-containing protein 2; SMYD2; KMT3C

• Gene Name:

  SMYD2

• UniProt:

  Q9NRG4

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human SMYD2. AA range:99-148

• Applications:

  WB

• Purification:

  Immunogen affinity purified

• Form:

  Liquid

• Function:

  Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2) . Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. .

• Molecular Weight:

  49688 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Fragment:

  IgG

• Other Gene Names:

  N-lysine methyltransferase SMYD2

• Subcellular Location:

  Cytoplasm, cytosol . Nucleus .