Anti-NCK2/Nck Beta Antibody

• Background:

  Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.
  
  Susanne Frese, J. Biol. Chem., Jun 2006; 281: 18236 - 18245.
  Friedhelm Bladt, Mol. Cell. Biol., Jul 2003; 23: 4586 - 4597.
  Stephan J. Kempiak, J. Biol. Chem., Feb 2005; 280: 5836 - 5842.
  Min Chen, Mol. Cell. Biol., Nov 2000; 20: 7867 - 7880.

• Description:

  Boster Bio Anti-NCK2/Nck Beta Antibody (Catalog # A04036) . Tested in IHC applications. This antibody reacts with Human.

• Synonyms:

  Cytoplasmic protein NCK2; Growth factor receptor-bound protein 4; NCK adaptor protein 2; Nck-2; SH2/SH3 adaptor protein NCK-beta; NCK2; GRB4

• Gene Name:

  NCK2

• UniProt:

  O43639

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthesized peptide derived from C-terminal of human NCK2.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitous.

• Applications:

  IHC

• Field of Research:

  Actin Assembly, Actin, etc., Adapters, Cancer, Cancer Susceptibility, Cell Biology, Cell Cycle, Cell Cycle Inhibitors, Cell Type Markers, Cytoplasmic, Cytoskeleton, Cytoskeleton/ECM, Epigenetics and Nuclear Signaling, Microfilaments, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Signal Transduction, Tags & Cell Markers, Transcription, Tumor Associated

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  Immunohistochemistry: 1:50~1:100

• Form:

  Liquid

• Function:

  Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1- dependent transcriptional activation in response to activated Ras signaling. .

• Molecular Weight:

  42915 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Cytoplasmic protein NCK2

• Subcellular Location:

  Cytoplasm . Endoplasmic reticulum .