Anti-Prostate Apoptosis Response Protein-4 PAWR Antibody

• Background:

  Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
  
  Hongzhe Li, J. Biol. Chem., Feb 2007; 282: 4943 - 4950.
  Wuhan Xiao, Cancer Res., Aug 2003; 63: 4698 - 4704.
  Thierry Virolle, J. Biol. Chem., Mar 2003; 278: 11802 - 11810.
  Derek J. Richard, Genes & Dev., Feb 2001; 15: 328.

• Description:

  Boster Bio Anti-Prostate Apoptosis Response Protein-4 PAWR Antibody (Catalog # A03637) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  PRKC apoptosis WT1 regulator protein; Prostate apoptosis response 4 protein; Par-4; PAWR; PAR4

• Gene Name:

  PAWR

• UniProt:

  Q96IZ0

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from human prostate apoptosis response protein-4.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. .

• Applications:

  WB, IHC

• Field of Research:

  Apoptosis, Cancer, Cell Biology, Cell Cycle, Cell Death, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Metabolism, Metabolism Processes, Nuclear, Nucleus, Pathways and Processes, Transcription

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. .

• Molecular Weight:

  36568 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  PRKC apoptosis WT1 regulator protein

• Subcellular Location:

  Cytoplasm. Nucleus. Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis (By similarity) . Nuclear localization includes nucleoplasm and PML nuclear bodies. .