Anti-ZMY11 ZMYND11 Antibody

• Background:

  Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) By similarity. Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.
  
  Hateboer G., EMBO J. 14:3159-3169(1995).
  Deloukas P., Nature 429:375-381(2004).
  Matsuoka S., Science 316:1160-1166(2007).

• Description:

  Boster Bio Anti-ZMY11 ZMYND11 Antibody (Catalog # A02092-1) . Tested in IHC applications. This antibody reacts with Human, Mouse.

• Synonyms:

  Zinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein BS69; ZMYND11; BRAM1, BS69

• Gene Name:

  ZMYND11

• UniProt:

  Q15326

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  Synthesized peptide derived from internal of human ZMY11.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Ubiquitous. .

• Applications:

  IHC

• Field of Research:

  Antiviral Signaling, Cell Biology, Cell Cycle, Cell Cycle Inhibitors,2339, Epigenetics and Nuclear Signaling, Immune System Diseases, Immunology, Pol II Transcription, Polymerase Associated Factors, RNA Polymerase, Transcription, Transcription Factors

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Dilution:

  Immunohistochemistry: 1:50~1:100

• Form:

  Liquid

• Function:

  Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity) . Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. .

• Molecular Weight:

  70963 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Zinc finger MYND domain-containing protein 11

• Subcellular Location:

  Nucleus. Chromosome. Associates with chromatin and mitotic chromosomes.