Anti-AP-2 TFAP2A Antibody

• Background:

  Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
  
  ShunJiang Yu, J. Biol. Chem., May 2003; 278: 19597 - 19602.
  TT Chen, Mol. Cell. Biol., Jun 1997; 17: 3056 - 3064.
  Oscar B. Goodman, J. Biol. Chem., Oct 1995; 270: 23768.
  Didier Jean, J. Biol. Chem., Jun 1998; 273: 16501

• Description:

  Boster Bio Anti-AP-2 TFAP2A Antibody (Catalog # A01167-1) . Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Transcription factor AP-2-alpha; AP2-alpha; AP-2 transcription factor; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; TFAP2A; AP2TF, TFAP2

• Gene Name:

  TFAP2A

• UniProt:

  P05549

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthesized peptide derived from human AP-2.

• Clonality:

  Polyclonal

• Applications:

  WB, IHC

• Field of Research:

  2339, Epigenetics and Nuclear Signaling, Transcription

• Purification:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration:

  1 mg/ml

• Form:

  Liquid

• Function:

  Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. .

• Molecular Weight:

  48062 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

• Other Gene Names:

  Transcription factor AP-2-alpha

• Subcellular Location:

  Nucleus .