Human sL-Selectin PicoKine® Quick ELISA Kit

• Background:

  L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by ADAM17.SELL (L-selectin) is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.1L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point2.

• Description:

  Human sL-Selectin PicoKine® Quick ELISA Kit (90 minutes, 96 Tests) . Quantitate Human SELL in cell culture supernatants, serum and plasma (heparin, EDTA, citrate) . Sensitivity: 5pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD62L; SELL; LNHR, LYAM1

• Gene Name:

  L-selectin

• UniProt:

  P14151

• Reactivity:

  Human

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: W39-N332

• Tissue Specificity:

  Expressed in B-cell lines and T-lymphocytes. .

• Applications:

  ELISA

• Sample Type:

  Cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

• Detection Range:

  62.5 pg/ml - 4,000 pg/ml

• Sensitivity:

  <5 pg/ml

• Function:

  Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. .

• Storage Conditions:

  Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

• Other Gene Names:

  SELL

• Subcellular Location:

  Membrane; Single-pass type I membrane protein.

• Sequence Similarities:

  Belongs to the selectin/LECAM family.

• Protein Name:

  L-selectin