Monkey primate Epiregulin ELISA Kit PicoKine®

• Background:

  Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene. It is a member of the epidermal growth factor family. Epiregulin can function as a ligand of epidermal growth factor receptor (EGFR), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. The secondary structure at the C-terminus epiregulin is different from other epidermal growth factor family ligands because of the lack of hydrogen bonds. The structural difference at the C-terminus may provide an explanation for the reduced binding affinity of epiregulin to the ERBB receptors.

• Description:

  Monkey primate Epiregulin ELISA Kit PicoKine® (96 Tests) . Quantitate Monkey EREG in cell culture supernatants, serum and plasma (heparin, EDTA) . Sensitivity: 0.5pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Proepiregulin; Epiregulin; EPR; EREG

• Gene Name:

  Proepiregulin

• UniProt:

  O14944

• Reactivity:

  Monkey

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: E.coli; Immunogen sequence: V60-L108

• Tissue Specificity:

  In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon. .

• Applications:

  ELISA

• Field of Research:

  Cancer, Growth Factors/Hormones, Signal Transduction, Tumor Biomarkers

• Sample Type:

  Cell culture supernatants, serum and plasma (heparin, EDTA) .

• Detection Range:

  3.9 pg/ml - 250 pg/ml

• Sensitivity:

  <10 pg/ml

• Function:

  Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975) . Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357) . .

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  EREG

• Subcellular Location:

  Epiregulin: Secreted, extracellular space .

• Protein Name:

  Proepiregulin