Human B2M / beta 2 Microglobulin ELISA Kit PicoKine®

Human B2M / beta 2 Microglobulin ELISA Kit PicoKine®

• Background: Beta-2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells). In humans, the beta-2-microglobulin protein is encoded by the B2M gene. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
• Description: Human B2M / beta 2 Microglobulin ELISA Kit PicoKine® (96 Tests). Quantitate Human B2M in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 10pg/ml . The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.
• Synonyms: Beta-2-microglobulin; Beta-2-microglobulin form pI 5.3; B2M; CDABP0092; HDCMA22P
• CAS Number: 7732-18-5
• Gene Name: beta-2-microglobulin
• Gene ID: 567
• UniProt: P61769
• Reactivity: Human
• Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.
• Immunogen: Target protein isolated from human plasma
• Applications: ELISA
• Sample Type: cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk.
• Detection Range: 156 pg/ml - 10,000 pg/ml
• Sensitivity: <10 pg/ml
• : heparin or EDTA
• Function: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).
• Reproducibility:

  Lots	Lot 1 (pg/ml)	Lot 2 (pg/ml)	Lot 3 (pg/ml)	Lot 4 (pg/ml)	Mean (pg/ml)	Standard Deviation	CV (%)
  Sample 1	293	284	309	337	305	20.14	6.6%
  Sample 2	1070	1104	1006	1045	1056	35.77	3.3%
  Sample 3	5097	4645	4569	4545	4714	224.18	4.7%

  *number of samples for each test n=16.
• Storage Conditions: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
• Specificity: Natural and recombinant human B2M