Human MyD88 ELISA Kit PicoKine®

• Background:

  Myeloid differentiation primary response gene (88) (MYD88) is a protein that, in humans, is encoded by the MYD88 gene. By interspecific backcross mapping, the mouse MyD88 gene was localized to chromosome 9; the human homolog was mapped to 3p22-p21.3 The human ortholog MYD88 seems to function similarly to mice, however, available evidence suggests that MYD88 is dispensable for human resistance to common viral infections and to all but a few pyogenic bacterial infections, demonstrating a major difference between mouse and human immune responses.

• Description:

  Human MyD88 ELISA Kit PicoKine® (96 Tests) . Quantitate Human MYD88 in cell culture supernatants, cell lysates, bone tissue, serum and plasma (heparin, EDTA) . Sensitivity: 10pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Myeloid differentiation primary response protein MyD88; MYD88

• Gene Name:

  Myeloid differentiation primary response protein MyD88

• UniProt:

  Q99836

• Reactivity:

  Human

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: E.coli; Immunogen sequence: M1-P296

• Tissue Specificity:

  Ubiquitous. .

• Applications:

  ELISA

• Field of Research:

  Adapters, Atherosclerosis, Cardiovascular, Cytoplasmic, Immunology, Innate Immunity, Signal Transduction, TLR Signaling, Vascular Inflammation

• Sample Type:

  Cell culture supernatants, cell lysates, bone tissue, serum and plasma (heparin, EDTA)

• Detection Range:

  156 pg/ml - 10,000 pg/ml

• Sensitivity:

  <10 pg/ml

• Function:

  Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. .

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  MYD88

• Subcellular Location:

  Cytoplasm .

• Sequence Similarities:

  Contains 1 death domain.

• Protein Name:

  Myeloid differentiation primary response protein MyD88