Human FLRG/FSTL3 ELISA Kit PicoKine®

• Background:

  FSTL3 (Follistatin-Like 3) also known as FLRG or FOLLISTATIN-RELATED GENE, is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. The FSTL3 gene extends over 7 kbp and contains 5 exons. The FSTL3 gene was localized to chromosome 19p13. This gene involved in hematopoiesis and in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. It may have a role in leukemogenesis.

• Description:

  Human FLRG/FSTL3 ELISA Kit PicoKine® (96 Tests) . Quantitate Human FSTL3 in cell culture supernatants, serum, plasma (heparin, EDTA), urine and human milk. Sensitivity: 10pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Follistatin-related protein 3; Follistatin-like protein 3; Follistatin-related gene protein; FSTL3; FLRG; UNQ674/PRO1308

• Gene Name:

  Follistatin-related protein 3

• UniProt:

  O95633

• Reactivity:

  Human

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: M27-V263

• Tissue Specificity:

  Expressed in a wide range of tissues. .

• Applications:

  ELISA

• Field of Research:

  Growth Factors/Hormones, Hematopoietic Progenitors, Lymphoid, Mesenchymal Stem Cells, Signal Transduction, Stem Cells

• Sample Type:

  Cell culture supernatants, serum, plasma (heparin, EDTA), urine and human milk.

• Detection Range:

  62.5 pg/ml - 4,000 pg/ml

• Sensitivity:

  <10 pg/ml

• Function:

  Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. .

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  FSTL3

• Subcellular Location:

  Isoform 1: Secreted.

• Sequence Similarities:

  Contains 2 follistatin-like domains.

• Protein Name:

  Follistatin-related protein 3