Human CD40/TNFRSF5 ELISA Kit PicoKine®

• Background:

  CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B-cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells. The CD40 gene is localized to the long arm of chromosome 20, bands q12-q13.2. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

• Description:

  Human CD40/TNFRSF5 ELISA Kit PicoKine® (96 Tests) . Quantitate Human CD40 in cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk. . Sensitivity: 1pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Tumor necrosis factor receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40; CD40; CD40; TNFRSF5

• Gene Name:

  Tumor necrosis factor receptor superfamily member 5

• UniProt:

  P25942

• Reactivity:

  Human

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: E21-R193

• Tissue Specificity:

  B-cells and in primary carcinomas.

• Applications:

  ELISA

• Field of Research:

  Adaptive Immunity, Atherosclerosis, B Cells, Cardiovascular, Hematopoietic Progenitors, Immunology, Lymphoid, Myeloid, Stem Cells, Vascular Inflammation

• Sample Type:

  Cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk.

• Detection Range:

  15.6 pg/ml - 1,000 pg/ml

• Sensitivity:

  <1 pg/ml

• Function:

  Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  CD40

• Subcellular Location:

  Isoform I: Cell membrane; Single-pass type I membrane protein.

• Sequence Similarities:

  Contains 4 TNFR-Cys repeats.

• Protein Name:

  Tumor necrosis factor receptor superfamily member 5