Mouse CD30L ELISA Kit PicoKine®

• Background:

  The human CD30L (CD153) gene is located at 9q33. It contains 4 exons and spans more than 17.1 kb. CD153 is expressed on the surface of B cells and this expression is upregulated upon CD154 (CD40LG), IL4, and B-cell receptor engagement. In these cells, engagement of CD153 by T cell CD30 inhibits immunoglobulin class switch recognition as well as IgG, IgA, and IgE production, suggesting that this"reverse signaling" modulates the CD154-dependent switching of B cells into the pool producing IgG, IgA, and IgE. Additionally, recombinant human CD30L enhanced the proliferation of CD3 -activated T cells, but induced differential responses, including cell death, in several CD30-positive lymphoma-derived cell lines.The standard product used in this kit is recombinant mouse CD30L with the molecular mass of 30-45KDa.

• Description:

  Mouse CD30L ELISA Kit PicoKine® (96 Tests) . Quantitate Mouse Tnfsf8 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) . Sensitivity: 6pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; CD153; Tnfsf8; Cd30l, Cd30lg

• Gene Name:

  Tumor necrosis factor ligand superfamily member 8

• UniProt:

  P32972

• Reactivity:

  Mouse

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: Q68-D239

• Applications:

  ELISA

• Field of Research:

  Adaptive Immunity, Immunology, T Cells

• Sample Type:

  Cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) .

• Detection Range:

  15.6 pg/ml - 1,000 pg/ml

• Sensitivity:

  <6 pg/ml

• Function:

  Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  TNFSF8

• Subcellular Location:

  Membrane; Single-pass type II membrane protein.

• Protein Name:

  Tumor necrosis factor ligand superfamily member 8