Mouse OPG (TNFRSF11B) / Osteoprotegerin ELISA Kit PicoKine®

• Background:

  Osteoprotegerin (OPG) is identical to osteoclastogenesis inhibitory factor (OCIF), a soluble member of the tumor-necrosis factor receptor family that inhibits osteoclastogenesis. OPG is considered to play an important role in the regulation of bone resorption by modifying osteoclast differentiation. Osteoprotegerin is an independent risk factor for the progression of atherosclerosis and onset of cardiovascular disease. It can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity. OPG system may play a critical role in the development of osteolytic bone disease in multiple myeloma and that targeting this system may have therapeutic potential. OPG also plays a role in the vascular system.

• Description:

  Mouse OPG (TNFRSF11B) / Osteoprotegerin ELISA Kit PicoKine® (96 Tests) . Quantitate Mouse Tnfrsf11b in cell culture supernatants, serum and plasma (EDTA) . Sensitivity: 5pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Tumor necrosis factor receptor superfamily member 11B; Osteoclastogenesis inhibitory factor; Osteoprotegerin; Tnfrsf11b; Ocif, Opg

• Gene Name:

  Tumor necrosis factor receptor superfamily member 11B

• UniProt:

  O08712

• Reactivity:

  Mouse

• Cross Reactivity:

  There is no detectable cross-reactivity with other relevant proteins.

• Immunogen:

  Expression system for standard: NS0; Immunogen sequence: E22-L401

• Tissue Specificity:

  Highly expressed in liver, lung, stomach, intestines and calvaria. Highly expressed in decidua and placenta, and in embryo.

• Applications:

  ELISA

• Field of Research:

  Atherosclerosis, Cardiovascular, Cytokines, Cytoskeleton/ECM, Extracellular Matrix, Immunology, Innate Immunity, Metabolism, Obesity, Signal Transduction, Structures, TNF Superfamily, Vascular Inflammation

• Sample Type:

  Cell culture supernatants, serum and plasma (EDTA) .

• Detection Range:

  93.7 pg/ml - 6,000 pg/ml

• Sensitivity:

  <5 pg/ml

• Function:

  Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. .

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  TNFRSF11B

• Subcellular Location:

  Secreted.

• Sequence Similarities:

  Contains 2 death domains.

• Protein Name:

  Tumor necrosis factor receptor superfamily member 11B