Mouse IGF-2 ELISA Kit PicoKine®

• Background:

  Insulin-like growth factor II is also known as somatomedin A. IGF-2 is a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is paternally expressed in the fetus and placenta. IGF-II is a mitogen for many cell types and an important modulator of muscle growth and differentiation. IGF-II gene is prevalently expressed during prenatal development and its gene activity is regulated by genomic imprinting, in that the allele inherited from the father is active and the allele inherited from the mother is inactive in most normal tissues. IGF-II appears to be induced by placental lactogen during prenatal development. It is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in breast cancers, are components of a developmental pathway in the mammary gland.

• Description:

  Mouse IGF-2 ELISA Kit PicoKine® (96 Tests) . Quantitate Mouse Igf2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) . Sensitivity: 5pg/ml. The brand Picokine indicates this is a premium quality ELISA kit. Each Picokine kit delivers precise quantification, high sensitivity, and excellent reproducibility. Only our most reliable and effective kits qualify as Picokine, guaranteeing top-tier results for your assays.

• Synonyms:

  Insulin-like growth factor II; IGF-II; Multiplication-stimulating polypeptide; Insulin-like growth factor II; Preptin; Igf2; Igf-2

• Gene Name:

  Insulin-like growth factor II

• UniProt:

  P09535

• Reactivity:

  Mouse

• Cross Reactivity:

  There is no detectable cross-reactivity with IGF-1.

• Immunogen:

  Expression system for standard: E.coli; Immunogen sequence: A25-E91

• Applications:

  ELISA

• Field of Research:

  Signal Transduction

• Sample Type:

  Cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA) .

• Detection Range:

  62.5 pg/ml - 4,000 pg/ml

• Sensitivity:

  <5 pg/ml

• Function:

  The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.

• Storage Conditions:

  Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

• Other Gene Names:

  IGF2

• Subcellular Location:

  Secreted.

• Protein Name:

  Insulin-like growth factor II