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EBOV-IN-1

CAT: 0804-HY-W395779Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W395779Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV) . EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM[1].
CAS Number
1335113-30-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Filovirus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ebov-in-1.html
Purity
98.55
Solubility
10 mM in DMSO
Smiles
COC(=O)C1=CC=C(COC2=CC=CC=C2CN2CCN(C(=O)CNC(=O)CC34CC5CC(CC(C5)C3)C4)CC2)C=C1
Molecular Formula
C34H43N3O5
Molecular Weight
573.72
Precautions
H302, H315, H319, H335
References & Citations
[1]Liu H, et al. Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies. J Med Chem. 2018 Jul 26;61 (14) :6293-6307.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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