Anti-Insulin Ins2 Antibody (Monoclonal, K36AC10)

• Background:

  Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. The insulin gene contains 3 exons and 2 introns; exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Harper et al. (1981) and Harper and Saunders (1981) assigned the insulin gene to 11p15.5 by in situ hybridization.

• Description:

  Boster Bio Anti-Insulin Ins2 Antibody (Monoclonal, K36AC10) catalog # MA1052. Tested in IHC applications. This antibody reacts with Human, Rabbit, Rat.

• Synonyms:

  Insulin-2; Insulin-2 B chain; Insulin-2 A chain; Ins2; Ins-2

• Gene Name:

  Insulin-2

• UniProt:

  P01323

• Host:

  Mouse

• Reactivity:

  Human, Rabbit, Rat

• Cross Reactivity:

  No cross-reactivity with other proteins

• Immunogen:

  Human insulin.

• Clonality:

  Monoclonal

• Clone:

  Clone: K36AC10

• Applications:

  IHC

• Field of Research:

  Cancer, Chaperones, Heat Shock Proteins, Protein Trafficking, Signal Transduction, Tumor Biomarkers

• Purification:

  Ascites

• Concentration:

  Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

• Form:

  Lyophilized

• Reconstitution:

  Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

• Function:

  Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

• Storage Conditions:

  Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

• Fragment:

  Mouse IgG1

• Applications Notes:

  Immunohistochemistry (Paraffin-embedded Section), 0.4-1μg/ml, Human, rabbit, rat, By Heat
  

• Other Gene Names:

  INS

• Subcellular Location:

  Secreted.

• Sequence Similarities:

  Belongs to the insulin family.

• Protein Name:

  Insulin