SAHM1

CAT: 0804-HY-P2203-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P2203-01Size:1 mg
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Description
SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice[1][2].
CAS Number
[2050906-89-1]
UNSPSC
12352209
Target
Notch
Type
Peptides
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sahm1.html
Purity
96.40
Solubility
10 mM in DMSO
Smiles
C[C@@H](O)[C@@H](C(O)=O)NC([C@H](CO)NC([C@H](CC1=CN=CN1)NC([C@@H](NC([C@]2(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](C)(CCC/C=C/CCC2)NC([C@H]([C@@H](C)CC)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(O)=O)NC(CCNC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CS)=O)CCCNC(N)=N)=O)C)=O)CC3=CN=CN3)=O)=O)=O
Molecular Formula
C94H162N36O23S
Molecular Weight
2196.58
References & Citations
[1]Ashley JW, et, al. Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem. 2015 Nov;116 (11) :2598-609.|[2]KleinJan A, et, al. The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J Allergy Clin Immunol. 2018 Jul;142 (1) :76-85.e8.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

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