ZIP

• Description :

  ZIP is a selective peptide inhibitor of PKMζ. ZIP injections can block the impairment in morphine conditioned place preference induced[1].

• UNSPSC :

  12352209

• Target :

  PKC

• Type :

  Peptides

• Related Pathways :

  Epigenetics; TGF-beta/Smad

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/zip.html

• Purity :

  98.05

• Solubility :

  H2O : 6.25 mg/mL (ultrasonic)

• Smiles :

  CC(C)C[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](C)NC(CNC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC(CCCCCCCCCCCCC)=O)=O)=O)CC1=CC=C(C=C1)O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O

• Molecular Formula :

  C90H154N30O17

• Molecular Weight :

  1928.38

• References & Citations :

  [1]Li Y, et, al. Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory. J Neurosci. 2011 Apr 6;31 (14) :5436-46.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  Phase 4

• CAS Number :

  [863987-12-6]