Nordihydroguaiaretic acid
CAT:
804-HY-N0198-01
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Nordihydroguaiaretic acid
- CAS Number: 500-38-9
- UNSPSC Description: Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC50=8 μM) and tyrosine kinase inhibitor.
- Target Antigen: Autophagy; Ferroptosis; Lipoxygenase
- Type: Natural Products
- Related Pathways: Apoptosis;Autophagy;Metabolic Enzyme/Protease
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/nordihydroguaiaretic-acid.html
- Purity: 99.93
- Solubility: DMSO : 250 mg/mL (ultrasonic)
- Smiles: CC(CC1=CC=C(O)C(O)=C1)C(C)CC2=CC=C(O)C(O)=C2
- Molecular Weight: 302.36
- References & Citations: [1]West M, et al. The arachidonic acid 5-lipoxygenase inhibitor Nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem. 2004 Oct;91(1):133-43.|[2]Lu F, et al. Virtual Screening for Potential Allosteric Inhibitors of Cyclin-Dependent Kinase 2 from Traditional Chinese Medicine. Molecules. 2016 Sep 21;21(9). pii: E1259.|[3]Zhang H, et al. Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARα-dependent and -independent pathways. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G72-86.
- Shipping Conditions: Room Temperature
- Storage Conditions: Store at room temperature 3 years
- Clinical Information: Launched