Products for Research Use Only
RegisterLogin

PS210

CAT: 0804-HY-121629-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-121629-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PS210 is a potent and selective PDK1 activator with a Kd of 3 μM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K[1][2].
CAS Number
1221962-86-2
UNSPSC
12352005
Target
PDK-1
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ps210.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(C(O)=O)C(CC(C1=CC=C(C=C1)C(F)(F)F)=O)C2=CC=CC=C2)O
Molecular Formula
C19H15F3O5
Molecular Weight
380.31
References & Citations
[1]Busschots K, et al. Substrate-selective inhibition of protein kinase PDK1 by small compounds that bind to the PIF-pocket allosteric docking site. Chem Biol. 2012 Sep 21;19 (9) :1152-63.|[2]Rettenmaier TJ, et al. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proc Natl Acad Sci U S A. 2014 Dec 30;111 (52) :18590-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-174248PS21M
HY-153324PS220 (sodium)
HY-P701034WFDC1/PS20, Cynomolgus (His)
HY-P78025-01WFDC1/PS20, Mouse (His)
HY-P78024-01WFDC1/PS20, Human (His)

Alternative Products

CatalogName
BA8728-5.1PS210
A22109-50PS210 50mg
A22109-25PS210 25mg
A22109-2PS210 2mg
GTR19205005-01(R) -PS210
A22109-100PS210 100mg
A22109-10PS210 10mg
A22109-5PS210 5mg
A22109-1PS210 1mg
MBS5767442(R)-PS210

Popular Products