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HSDVHK-NH2

CAT: 0804-HY-P1187-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1187-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM) [1][2].
CAS Number
848644-86-0
UNSPSC
12352209
Target
Integrin
Type
Peptides
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hsdvhk-nh2.html
Purity
99.54
Solubility
H2O : 250 mg/mL (ultrasonic)
Smiles
NCCCC[C@@H](C(N)=O)NC([C@H](CC1=CNC=N1)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](CO)NC([C@H](CC2=CNC=N2)N)=O)=O)=O)=O)=O
Molecular Formula
C30H48N12O9
Molecular Weight
720.78
References & Citations
[1]Yoonsuk Lee, et al. High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J Biomol Screen. 2004 Dec;9 (8) :687-94.|[2]Youngjin Choi, et al. Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics. 2010 Jan;10 (1) :72-80.|[3]Ji-Young Bang, et al. Pharmacoproteomic analysis of a novel cell-permeable peptide inhibitor of tumor-induced angiogenesis. Mol Cell Proteomics. 2011 Aug;10 (8) :M110.005264.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
αvβ3

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