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Nikkomycin Z

CAT: 0804-HY-19593-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19593-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nikkomycin Z is a nucleoside peptide and an orally active antifungal agent. Nikkomycin Z inhibits chitin synthesis by acting as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine. Nikkomycin Z has antifungal activity[1][2][3].
CAS Number
59456-70-1
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nikkomycin-z.html
Purity
98.62
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@H](O)[C@@H]([C@@H](C(O)=O)NC([C@@H](N)[C@@H]([C@H](O)C2=NC=C(O)C=C2)C)=O)O[C@H]1N3C(NC(C=C3)=O)=O
Molecular Formula
C20H25N5O10
Molecular Weight
495.44
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]R Kovács, et al. Synergistic Effect of Nikkomycin Z With Caspofungin and Micafungin Against Candida Albicans and Candida Parapsilosis Biofilms. Lett Appl Microbiol. 2019 Oct;69 (4) :271-278.|[2]Nix DE, et al. Pharmacokinetics of nikkomycin Z after single rising oral doses. Antimicrob Agents Chemother. 2009 Jun;53 (6) :2517-21.|[3]Goldberg J, et al. Comparison of nikkomycin Z with amphotericin B and itraconazole for treatment of histoplasmosis in a murine model. Antimicrobial Agents and Chemotherapy, 2000, 44 (6) : 1624-1629.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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