Levamisole

• UNSPSC Description:

  Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active[1][2].

• Target Antigen:

  nAChR; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-minus-levamisole.html

• Purity:

  99.96

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C12=N[C@@H](C3=CC=CC=C3)CN1CCS2

• Molecular Weight:

  204.298

• References & Citations:

  [1]Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017;23(12):1869-1872. |[2]Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986;61(2):153-158. Rapid Commun Mass Spectrom. 2022 Nov 16;e9430.|bioRxiv. 2023 Oct 15.|Environ Sci Pollut Res Int. 2022 Sep 16.|J Ethnopharmacol. 2024 Jun 3:118406.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  14769-73-4