SIC5-6

SIC5-6

• CAS Number: 2410846-16-9
• UNSPSC Description: SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target[1].
• Target Antigen: Separase
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sic5-6.html
• Smiles: O=[S](N1CCC(C2=CNC3=CC=CC=C23)(C4=CNC5=CC=CC=C45)CC1)(C(C=C6)=CC=C6I)=O
• Molecular Weight: 581.47
• References & Citations: [1]Henschke L, et al. Identification of Bioactive Small Molecule Inhibitors of Separase. ACS Chem Biol. 2019 Oct 18;14(10):2155-2159.
• Shipping Conditions: Room Temperature