IFN-alpha 4/IFNA4, Rat (HEK293, Fc)

IFN-alpha 4/IFNA4, Rat (HEK293, Fc)

• UNSPSC Description: IFN-alpha 4 (IFNA4), belongs to type I interferon family, is produced by macrophages with antiviral activities[1]. IFN-alpha 4/IFNA4 Protein, Rat (HEK293, Fc) contains 166 a.a. (C24-K189), produced in HEK293 cells with a N-terminal hFc-tag.
• Type: Recombinant Proteins
• Assay Protocol: https://www.medchemexpress.com/cytokines/ifn-alpha-4-ifna4-protein-rat-hek293-fc.html
• Purity: 97.00
• Smiles: CDLPPTLNLR NKRAFTLLAQ MRRLSPVSCL KDRQDFGFPQ EKVDAQQIQK AQTIPVLHEL SQQVLNIFTS KDSSAAWNAT LLDSFCNDLH QQLSDLKVCL MQQVGMQEPP LTQEDSLLAV REYFHRITVY LTEKKHSPCA WEVVRAEVWR ALSSSVYLLA KLSEEK
• Molecular Weight: Approximately 48-53 kDa due to the glycosylation.
• References & Citations: [1]Zhang SY, et al. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev. 2008 Dec;226:29-40.|[2]Raj NB, et al. Identification of a novel virus-responsive sequence in the promoter of murine interferon-alpha genes. J Biol Chem. 1991 Jun 15;266(17):11360-5.|[3]Li Y, et al. Expression Pattern of Individual IFNA Subtypes in Chronic HIV Infection. J Interferon Cytokine Res. 2017 Dec;37(12):541-549.|[4]Verhagen A, et al. Comparison of augmentation of human natural killer cell cytotoxicity by interferon-alpha subtypes. Nat Immun Cell Growth Regul. 1990;9(5):325-33.|[5]Au WC, et al. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11657-61.|[6]Lin R, et al. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Mol Cell Biol. 2000 Sep;20(17):6342-53.
• Shipping Conditions: Blue Ice
• Storage Conditions: Stored at -20°C for 2 years