Morin

• Description:

  Morin is an orally active plant-derived flavonoid. Morin inhibits ROS generation. Morin induces Apoptosis. Morin inhibits PTP1B (IC50 of 15 μM) and activates the insulin receptor. Morin has a detoxifying effect. Morin can be used in diabetes, leukemia, colon cancer, cervical cancer, Parkinson's disease and hypertension research[1][2][3][4][5][6][7][8][9][10][11][12].

• UNSPSC:

  12352005

• Hazard Statement:

  H411

• Target:

  Apoptosis; Insulin Receptor; Phosphatase; Reactive Oxygen Species (ROS)

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/morin.html

• Purity:

  98.11

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C1C (O) =C (C2=CC=C (O) C=C2O) OC3=CC (O) =CC (O) =C13

• Molecular Formula:

  C15H10O7

• Molecular Weight:

  302.24

• Precautions:

  H411

• References & Citations:

  [1]Duthie G, et al. Antioxidant capacity of flavonoids in hepatic microsomes is not reflected by antioxidant effects in vivo. Oxid Med Cell Longev. 2012;2012:165127.|[2]Lian HZ, et al. Morin applied in speciation of aluminium in natural waters and biological samples by reversed-phase high-performance liquid chromatography with fluorescence detection. Anal Bioanal Chem. 2003 Jun;376 (4) :542-8. Epub 2003 May 9.|[3]Zhang R, et al. Cellular protection of morin against the oxidative stress induced by hydrogen peroxide. Chem Biol Interact. 2009 Jan 15;177 (1) :21-7.|[4]Kuo HM, et al. Morin inhibits the growth of human leukemia HL-60 cells via cell cycle arrest and induction of apoptosis through mitochondria dependent pathway. Anticancer Res. 2007 Jan-Feb;27 (1A) :395-405.|[5]Paoli P, et al. The insulin-mimetic effect of Morin: a promising molecule in diabetes treatment. Biochim Biophys Acta. 2013 Apr;1830 (4) :3102-11.|[6]Zhang Q, et al. Molecular mechanism of anti-cancerous potential of Morin extracted from mulberry in Hela cells. Food Chem Toxicol. 2018 Feb;112:466-475. |[7]Zhang ZT, et al. Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo. Acta Pharmacol Sin. 2010 Aug;31 (8) :900-6.|[8]Parihar VK, et al. Anticlastogenic activity of morin against whole body gamma irradiation in Swiss albino mice. Eur J Pharmacol. 2007 Feb 14;557 (1) :58-65.|[9]Merwid-Ląd A, et al. The effects of morin, a naturally occurring flavonoid, on cyclophosphamide-induced toxicity in rats. Advances in Clinical and Experimental Medicine, 2011, 20 (6) : 683-690. |[10]Prahalathan P, et al. Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study. Asian Pac J Trop Biomed. 2012 Jun;2 (6) :443-8. |[11]Kuzu M, et al. Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Biomed Pharmacother. 2018 Oct;106:443-453.|[12]Sreedharan V, et al. Effect of morin on tissue lipid peroxidation and antioxidant status in 1, 2-dimethylhydrazine induced experimental colon carcinogenesis. Invest New Drugs. 2009 Feb;27 (1) :21-30.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  480-16-0