AKR1B10-IN-1

AKR1B10-IN-1

• CAS Number: 2136579-33-2
• UNSPSC Description: AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells[1].
• Target Antigen: Aldose Reductase
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/akr1b10-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC2=CC=C(O)C=C2OC1=O)NCCCC3=CC=C(F)C=C3
• Molecular Weight: 341.33
• References & Citations: [1]Endo S, et al. Synthesis of Potent and Selective Inhibitors of Aldo-Keto Reductase 1B10 and Their Efficacy against Proliferation, Metastasis, and Cisplatin Resistance of Lung Cancer Cells [published correction appears in J Med Chem. 2018 Feb 8;61(3):1380]. J Med Chem. 2017;60(20):8441-8455.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported