VU 0240551

• Description:

  VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/VU-0240551.html

• Purity:

  99.70

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  O=C(CSC1=NN=C(C2=CC=CC=C2)C=C1)NC3=NC(C)=CS3

• Molecular Formula:

  C16H14N4OS2

• Molecular Weight:

  342.44

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [2]Wang Y, et al. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Neuroscience. 2015;298:397-409.|[3]Balapattabi K, et al. Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging. J Neuroendocrinol. 2019;31 (8) :e12752.|[1]Delpire E, et al. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106 (13) :5383-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  893990-34-6