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VU 0240551

CAT: 0804-HY-16689-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16689-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission[1][2].
CAS Number
893990-34-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/VU-0240551.html
Purity
99.70
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(CSC1=NN=C(C2=CC=CC=C2)C=C1)NC3=NC(C)=CS3
Molecular Formula
C16H14N4OS2
Molecular Weight
342.44
Precautions
H302, H315, H319, H335
References & Citations
[2]Wang Y, et al. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Neuroscience. 2015;298:397-409.|[3]Balapattabi K, et al. Effects of salt-loading on supraoptic vasopressin neurones assessed by ClopHensorN chloride imaging. J Neuroendocrinol. 2019;31 (8) :e12752.|[1]Delpire E, et al. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106 (13) :5383-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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MBS3845292-01VU 0240551
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A20854-200VU 0240551 200mg
A20854-500VU 0240551 500mg
A20854-50VU 0240551 50mg
A20854-5VU 0240551 5mg
A20854-100VU 0240551 100mg
A20854-25VU 0240551 25mg
A20854-10VU 0240551 10mg
A20854-1VU 0240551 1mg

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