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RO5527239

CAT: 0804-HY-116453Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-116453Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RO5527239 is an orally active TGR5 agonist, that induces a stimulatory response from intestinal L cells and specificially secrets the endogenous hormone GLP-2[1].
CAS Number
1354812-99-9
UNSPSC
12352005
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ro5527239.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCN(C2=CC=C([C@H](C3=CC=CC=C3C)C/C(C4=CC(C)=NC=C4)=N\O)C=C2)CC1)O
Molecular Formula
C28H31N3O3
Molecular Weight
457.56
References & Citations
[1]Hunt JE, et al., Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice. Am J Physiol Gastrointest Liver Physiol. 2020 May 1;318 (5) :G980-G987.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T26108-01RO5527239

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