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(1R,3S) -Compound E

CAT: 0804-HY-14176A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14176A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(1R,3S) -Compound E is the isomer of Compound E , and can be used as an experimental control. Compound E is a γ-secretase inhibitor. Compound E bloks β-amyloid (40), β-amyloid (42), and Notch γ-secretase cleavage with IC50s of 0.24, 0.37, 0.32 nM, respectively.
CAS Number
504428-17-5
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1r-3s-compound-e.html
Purity
99.82
Solubility
DMSO : ≥ 50 mg/mL
Smiles
FC1=CC(F)=CC(CC(N[C@H](C)C(N[C@H]2N=C(C3=CC=CC=C3)C4=CC=CC=C4N(C2=O)C)=O)=O)=C1
Molecular Formula
C27H24F2N4O3
Molecular Weight
490.50
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Beher D, et al. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. J Biol Chem. 2001 Nov 30;276 (48) :45394-402.|[2]Rasul S, et al. Inhibition of gamma-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells. Br J Cancer. 2009 Jun 16;100 (12) :1879-88.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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