Rocaglamide

CAT: 0804-HY-19356-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-19356-01Size:500 µg
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Description
Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. Rocaglamide is a potent inhibitor of NF-κB activation in T-cells. Rocaglamide is a potent and selective heat shock factor 1 (HSF1) activation inhibitor with an IC50 of ~50 nM. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also has anticancer properties in leukemia[1][2][3].
CAS Number
[84573-16-0]
Product Name Alternative
Roc-A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Eukaryotic Initiation Factor (eIF) ; HSP; NF-κB
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Rocaglamide.html
Purity
99.34
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@]12[C@](OC3=CC(OC)=CC(OC)=C32)(C4=CC=C(C=C4)OC)[C@H](C5=CC=CC=C5)[C@H]([C@H]1O)C(N(C)C)=O
Molecular Formula
C29H31NO7
Molecular Weight
505.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Santagata S, et al. Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state. Science. 2013 Jul 19; 341 (6143) : 1238303.|[2]Luan Z, et al. Rocaglamide overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance in hepatocellular carcinoma cells by attenuating the inhibition of caspase-8 through cellular FLICE-like-inhibitory protein downregulation. Mol Med Rep|[3]Baumann B, et al. Rocaglamide derivatives are potent inhibitors of NF-kappa B activation in T-cells. J Biol Chem. 2002 Nov 22;277 (47) :44791-800.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
EIF4; HSF1

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