Ketotifen

• Description :

  Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention[1][2][3][4].

• Product Name Alternative :

  HC 20-511

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Endogenous Metabolite; Histamine Receptor; Influenza Virus; SARS-CoV

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Infection; Endocrinology; Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ketotifen.html

• Purity :

  99.74

• Solubility :

  DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C1=C/2C=CS1)CC3=CC=CC=C3C2=C4CCN(C)CC/4

• Molecular Formula :

  C19H19NOS

• Molecular Weight :

  309.43

• Precautions :

  H315, H319, H320

• References & Citations :

  [4]Enkirch T, et al. Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity. Front Immunol. 2019 Jun 5;10:1097.|[5]Pinke KH, et al. Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy? Neurotherapeutics. 2020 Jan;17 (1) :218-234.|[1]Klooker TK, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59 (9) :1213-21.|[2]Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35 (1) :1322-1330.|[3]Kiani P, et al. In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2. Viruses. 2021 Mar 26;13 (4) :558.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  H1 Receptor

• Citation 01 :

  Cell Oncol (Dordr) . 2023 Oct;46 (5) :1445-1456.|Eur J Med Chem. 2024 Dec 5:279:116842.|Microbiol Spectr. 2024 May 23:e0063024.

• CAS Number :

  [34580-13-7]