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Ketotifen

CAT: 0804-HY-B0157-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0157-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ketotifen (HC 20-511) is an orally active second-generation noncompetitive histamine 1 (H1) receptor blocker and mast cell stabilizer. Ketotifen can block 6-phosphogluconate dehydrogenase (PGD) in vitro. Ketotifen also has antiviral activity against SARS-CoV-2 and Influenza virus. Ketotifen can be used to the research of autoimmune encephalomyelitis (EAE) and asthma attack prevention[1][2][3][4].
CAS Number
34580-13-7
Product Name Alternative
HC 20-511
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Endogenous Metabolite; Histamine Receptor; Influenza Virus; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Endocrinology; Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/ketotifen.html
Purity
99.74
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C/2C=CS1)CC3=CC=CC=C3C2=C4CCN(C)CC/4
Molecular Formula
C19H19NOS
Molecular Weight
309.43
Precautions
H315, H319, H320
References & Citations
[4]Enkirch T, et al. Identification and in vivo Efficacy Assessment of Approved Orally Bioavailable Human Host Protein-Targeting Drugs With Broad Anti-influenza A Activity. Front Immunol. 2019 Jun 5;10:1097.|[5]Pinke KH, et al. Calming Down Mast Cells with Ketotifen: A Potential Strategy for Multiple Sclerosis Therapy? Neurotherapeutics. 2020 Jan;17 (1) :218-234.|[1]Klooker TK, et al. The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut. 2010 Sep;59 (9) :1213-21.|[2]Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35 (1) :1322-1330.|[3]Kiani P, et al. In Vitro Assessment of the Antiviral Activity of Ketotifen, Indomethacin and Naproxen, Alone and in Combination, against SARS-CoV-2. Viruses. 2021 Mar 26;13 (4) :558.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor
Citation 01
Cell Oncol (Dordr) . 2023 Oct;46 (5) :1445-1456.|Eur J Med Chem. 2024 Dec 5:279:116842.|Microbiol Spectr. 2024 May 23:e0063024.

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